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Protein folding via charge zippers

Jan. 18, 2013 — Membrane proteins are the "molecular machines" in biological cell envelopes. They control diverse processes, such as the transport of molecules across the lipid membrane, signal transduction, and photosynthesis. Their shape, i.e. folding of the molecules, plays a decisive role in the formation of, e.g., pores in the cell membrane. In the journal Cell, researchers of Karlsruhe Institute of Technology and the University of Cagliari are now reporting a novel charge zipper principle used by proteins to form functional units. "It is fascinating to see the elegant basic principles that are used by nature to construct molecular assemblies," explains Anne Ulrich, Director of the KIT Institute for Biological Interfaces. "A charge zipper between the charged side chains is an entirely unexpected mechanism used by membrane proteins to neutralize their charges such that they can be immersed into hydrophobic cell membranes....
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Salmonella spreads by targeting cells in our gut, study shows

Dec. 11, 2012 — Scientists have gained fresh insights into how the salmonella bug makes us ill. University of Edinburgh researchers have found that the bacteria are able to change key cells that line the intestine, enabling the bugs to thrive. By changing the make-up of these cells, the salmonella bacteria are able to cross the gut wall. Food poisoning Salmonella food poisoning -- commonly caused by eating undercooked poultry or eggs -- can lead to diarrhea, fever and even death in young children. Scientists say the study furthers our understanding of how bacterial infections occur and what enables them to spread. Cellular make-up The University of Edinburgh research found that the salmonella released a protein -- SopB -- changing the make-up of certain cells that line the gut. This causes a dramatic increase in cells -- called microfold or M cells. The work, reveals how once the salmonella produces large number of these cells it can then ge...
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Lonza: CMC Product Manager

Due to the expansion of Lonza's Analytical Services department we are looking to recruit an Analytical Product Manager. Reporting to the Group Leader you will proactively coordinate internal and external client project activities (analytical CMC development of recombinant proteins) performed within Analytical Services and to provide scientific oversight of data generated for the projects. Responsibilities:      * Primary point of contact for all analytical activities relating to product development and management of analytical development programmes from early phase development through to license application.      * Primary interface to the Program Management Team, AS study directors and internal and external customers.      * Definition, presentation and representation of analytical CMC programmes to customers, potential new customers & external meetings, including oversight of large analytical portfolio projects.      * Design an...
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