Scientist Biotechnology (Computational Biologist) Job - BASF - Tarrytown, NY

Scientist Biotechnology (Computational Biologist)-1301862

BASF is proud to be an Affirmative Action and Equal Opportunity Employer.

Description
The position is being created to strengthen the Microbiology & Industrial Biotechnology Research Team in Tarrytown. The team is an integral part of BASF’s Fine Chemicals and Biocatalysis Research within the global Specialty Chemical Research Platform.

The team works closely with other research and development teams and business units of BASF, inside and outside the US. In addition, the team maintains and supports numerous collaborations with non-BASF partners, incl. universities and other research organizations.

The Computational Biology Scientist will develop computational tools to assist with Strains & Enzymes development for the production of bio-based chemicals within the Microbiology & Industrial Biotechnology Research Group.

Major Responsibilities
· Analyze and compare genome-wide next generation sequencing data (including assembly, annotation and data curation)
· Assist bench scientists via metabolic network rewiring for strain development using genomic, transcriptomic and metabolomic data analysis
· Work with global bioinformatics team to establish and incorporate existing tools into the North America White Biotech lab
· Develop and evaluate software solutions to manage data flood and turn it to meaningful actionable items
· Develop or acquire data mining tools for enzyme sequence activity relationship
· Develop or acquire computational tools to model kinetics of different pathways to highlight strain manipulations and recommend improvement strategies
- Interface and actively collaborate with other research and development units, including external and academic partners
- Actively participate in product development / cross functional teams
- Interface and actively collaborate with other research and development units, including external and academic partners
Qualifications - BASF recognizes institutions of Higher Education which are accredited by the Council for Higher Education Accreditation or equivalent

Required:
- Ph.D. in Computational Biology, Biochemical Engineering, Biochemistry or related discipline required
- 2+ years of experience working in an industrial lab or postdoctoral training of 3+ years required
- Working knowledge of computational programs such as Operating Systems required (e.g. UNIX, LINUX, Windows); Scripting languages (e.g. Perl, Python, Bash, Tcl); Programming languages (e.g. Java, C/C++)
- Experience in collecting and analyzing experimental data and use of computational tools required
- Thorough knowledge of research principles and techniques in strain engineering, cell metabolism, protein science and microbial physiology required
- Experience in programming biology related software for data mining (e.g. Genome sequences) required
- Understanding of what genomes are, what they do, and how they are relevant to genetic engineering required
- Self-starter and ability to work independently with minimal supervision
- Ability to manage and steer research projects
- Strong analytical and problem-solving skills
- Ability to work under strict timelines
- Excellent organizational and interpersonal communication skills

Desired:
- Hands on experience in system biology
- Experience in protein sequence activity relationship to address structural bioinformatics, computational protein design, protein engineering, protein evolution,
substrate docking, enzyme specificity
- Experience with molecular biology techniques for bacteria and yeast
- Experience with strain/enzyme rational or random evolution principles
- Experience with data analysis of metagenomic communities
- Knowledge of bioprocess engineering
- Familiarity with LIMS systems, Computational Design

Primary Location: United States-New York-Tarrytown
Function: APTE - Appl. Technology
Job Type: Standard
Shift: Day Job
Organization: N-GV-Specialty Chemicals Research

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