Astex Pharmaceuticals: Senior Analytical Chemist - Cambridge


Work for a company that is making a difference in the fight against cancer. Astex Pharmaceuticals, Inc. www.astx.com, brings together high tech and biotech to discover and develop more effective medicines for the treatment of cancer. At our Cambridge facility we utilize world-leading fragment-based drug discovery (FBDD). We are looking for a motivated, dedicated professional who wants to combine their skills with our uniquely talented team.  

Senior Analytical Chemist
We have an opportunity for someone to take leadership of small molecule analytical chemistry and be the company’s HPLC specialist. You will be a key member of our medicinal chemistry team and responsible for maintenance, operation and development of our open access LCMS systems. In addition you will conduct bespoke method development for challenging samples, providing separations and purity analysis. Additional responsibilities can be established based on the successful applicant’s interest and company priorities.

Responsibilities:
•    Developing analytical and preparative bespoke methods
•    Operation, maintenance and development of the department’s LCUV/ LCMS instruments
•    Support, education and advice for chemists with analytical and preparative LCMS
•    Optimisation of the equipment when changes of use required/ new consumables become available
•    Review new/ additional technologies for their usefulness at Astex
•    Advising the DMPK department in the optimisation of separation and equipment maintenance as required

Additional opportunities available according to the successful applicant’s skills and experience:
•    Ensure Astex has a ‘state-of-the-art’ separation science facility
•    Involvement with Astex CMC and analysis of clinical compounds
•    Cross-functional leadership of small molecule analysis group at Astex
•    HPLC-based physical property measurement assays including solubility and lipophilicity
•    Involvement in development of new biophysical methods
•    Involvement in fragment library maintenance and quality control
•    Career development opportunities are available within chemical analysis

Experience and Qualifications
You will have a BSc in Chemistry (or equivalent) and > 3 years’ experience working as a separation scientist preferably in a drug discovery laboratory
Experience working on analytical and preparative scale with both achiral and chiral chromatography is desirable
You should be comfortable working on your own whilst building close interactions with medicinal chemists

We offer competitive salaries plus extensive benefits including annual bonus, pension plan and private medical insurance.

To apply please send your CV and a covering letter and click the 'Apply now Button'
See our website for additional details:  www.astx.com

'Only candidates eligible to work in the UK will be considered'. 

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