Lonza: Cell Culture Development Scientist

A new opportunity has arisen for a Scientist to join our Cell Culture Development department, based in Slough, UK. As a Scientist you will provide laboratory-based practical expertise as well as scientific assessment. You will proactively seek alternative solutions to problems and makes decisions based on the best available scientific data.

About the Department:

The Cell Culture Development department at Lonza Biologics is a Global Centre of Excellence for the creation, development and characterisation of mammalian cell processes for the production of a wide variety of biopharmaceuticals. The department is responsible for the successful delivery of cell culture processes from pre-clinical stage to post commercial launch. The department’s 5 main disciplines are molecular biology, cell line construction, cell culture development, cell line characterisation and cell banking.

Key Responsibilities of the Role:

To complete experimental tasks to a high quality standard as directed and prepare customer communications for scientific assessment and decision making purposes. Key tasks will include:

Cell Line Construction:

•         Molecular Biology

•         Cell Culture

•         Transfection

•         Automated single cell sorting

•         Automated plate screening

•         Productivity assessments

•         Fed batch assessment (growth, productivity and product quality)

•         Cryopreservation of pre-seed stock

        Bioreactor:

•         Preparation of flask inoculum cell cultures

•         Set up and operation of inoculum cell culture bag bioreactors

•         Set-up and operation of miniature (15mL) up to 10L laboratory-scale bioreactors (stirred or air-lift)

•         Daily sampling and nutrient analysis

•         Nutrient feed preparation and additions

•         Harvest and primary recovery


Candidates will require a minimum of a BSc in a biological science or will have practical relevant experience. A theoretical knowledge or practical experience in upstream processing (eg. vector construction, transfection, cell line selection, operation of bioreactors, cell culture and aseptic processing, harvesting and primary recovery) would be an advantage but is not essential.

After training successful applicants would be expected to join weekend, bank holiday and on-call rotas.

During busy periods and after appropriate training you may be expected to undertake short term secondments in other departments within Process Development (Purification Development and Process Analytics).

Interested?

Lonza promotes a fast-paced, employee orientated environment and we take pride in both the quality of our products and the success of our employees. We offer a competitive remuneration package and encourage the development of individuals to help them achieve their full potential.

If you are interested in this opportunity please apply online via our careers page. Please ensure that you attach your CV to your profile.

Closing date: 15^th November 2013

Comments

Post a Comment

Popular posts from this blog

Protein folding via charge zippers

Jan. 18, 2013 — Membrane proteins are the "molecular machines" in biological cell envelopes. They control diverse processes, such as the transport of molecules across the lipid membrane, signal transduction, and photosynthesis. Their shape, i.e. folding of the molecules, plays a decisive role in the formation of, e.g., pores in the cell membrane. In the journal Cell, researchers of Karlsruhe Institute of Technology and the University of Cagliari are now reporting a novel charge zipper principle used by proteins to form functional units. "It is fascinating to see the elegant basic principles that are used by nature to construct molecular assemblies," explains Anne Ulrich, Director of the KIT Institute for Biological Interfaces. "A charge zipper between the charged side chains is an entirely unexpected mechanism used by membrane proteins to neutralize their charges such that they can be immersed into hydrophobic cell membranes....
Read more

Lonza: CMC Product Manager

Due to the expansion of Lonza's Analytical Services department we are looking to recruit an Analytical Product Manager. Reporting to the Group Leader you will proactively coordinate internal and external client project activities (analytical CMC development of recombinant proteins) performed within Analytical Services and to provide scientific oversight of data generated for the projects. Responsibilities:      * Primary point of contact for all analytical activities relating to product development and management of analytical development programmes from early phase development through to license application.      * Primary interface to the Program Management Team, AS study directors and internal and external customers.      * Definition, presentation and representation of analytical CMC programmes to customers, potential new customers & external meetings, including oversight of large analytical portfolio projects.      * Design an...
Read more

GlaxoSmithKline (GSK): Esprit Physician Leadership Development Programme

Esprit Physician Leadership Development Programme Are you an MBBS or MD with experience gained in a pharmaceutical, biotech or academic environment eager to become an outstanding leader? An inquisitive mind who would thrive on a diverse, intellectually demanding global leadership programme? Do you want to translate your medical expertise into disease-beating medicines? And help people across the world to do more, feel better and live longer? We are a science-led, global healthcare company that puts patients first. Our business is focused on developing medicines that improve the quality of human life. To meet the future strategic challenges this entails, we need to fast-track the finest medical talent into senior leadership roles within our business. The Esprit Physician programme is an initial three-year, accelerated, multi-disciplinary and individually tailored programme. It is heavily backed by our senior management team, and it will give you incredible standing as a phys...
Read more