Lonza: Cell Culture Senior Scientist

A great opportunity has opened up for a Senior Scientist to join our Cell Culture Development department. As an experienced lab based cell culture Scientist you will be expected to provide expert scientific and technical knowledge of cell culture processes and will be responsible for the delivery of customer projects.

About the Department:

The Cell Culture Development department at Lonza Biologics is a Global Centre of Excellence for the creation, development and characterisation of mammalian cell processes for the production of a wide variety of biopharmaceuticals. The department is responsible for the successful delivery of cell culture processes from pre-clinical stage to post commercial launch. The department’s 5 main disciplines are molecular biology, cell line construction, cell culture development, cell line characterisation and cell banking.

Key Responsibilities of the Role:

As a Senior Scientist you will develop expert scientific knowledge and flawless execution across a range of activities within Cell Culture Development, completing experimental stages of work to a high quality standard as defined by customer agreements.

Key tasks will include:

•         Simultaneously performing or directing several work programs with right first time quality

•         Working as part of a project team to complete projects on time and within budget

•         Representing Cell Culture Development at project meetings

•         Regularly communicating results by means of verbal presentations and written reports to both internal groups and to customers

•         Providing scientific guidance to more junior personnel as required

•         Writing protocols and reports

Cell Line Construction:

•         Cell Culture

•         Transfection

•         Single cell sorting

•         Automated screening

•         Growth, productivity and product quality assessments (shake-flask and miniature bioreactors)

•         Cryopreservation of cell stocks

        Bioreactor:

•         Set up and operation of cell culture bag bioreactors

•         Set-up and operation of miniature (15mL) and 10L laboratory-scale bioreactors (stirred or air-lift)

•         Daily monitoring and data analysis

•         Harvest and primary recovery

•         Process transfer

•         Process optimisation/development

Candidates will require a minimum of a BSc in a biological science and must have significant practical experience in cell culture or the production of recombinant proteins (including but not limited to monoclonal antibodies)

Ideally candidates will also have:

•         Theoretical knowledge or practical experience in upstream processing (eg. vector construction, transfection, cell line selection, operation of bioreactors, cell culture and aseptic processing, harvesting and primary recovery)

•         Some knowledge of GMP or similar quality systems

•         An awareness of technology transfer of processes from laboratory scale to manufacturing plants.

•         Process characterisation experience in line with current regulatory guidelines

After training, successful applicants would be expected to join weekend, bank holiday and on-call rotas.

During busy periods and after appropriate training you may be expected to undertake short term secondments in other departments within Process Development (Purification Development and Process Analytics).

Interested?

Lonza promotes a fast-paced, employee orientated environment and we take pride in both the quality of our products and the success of our employees. We offer a competitive remuneration package and encourage the development of individuals to help them achieve their full potential.

If you are interested in this opportunity please apply online via our careers page. Please ensure that you attach your CV to your profile.

Closing date: 15^th November 2013

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