Lonza: Cell Culture Development Technologist

A great opportunity has arisen for a Technologist to join our Cell Culture Development department, based in Slough, UK. The main responsibility of the role will be to provide flexible laboratory-based practical expertise within Cell Culture Development.

Cell Culture Development at Lonza Biologics is a Global Centre of Excellence for the creation, development and characterisation of mammalian cell processes for the production of a wide variety of biopharmaceuticals. The department is responsible for the successful delivery of cell culture processes from pre-clinical stage to post commercial launch. The department’s 5 main disciplines are molecular biology, cell line construction, cell culture development, cell line characterisation and cell banking.

Key Responsibilities:

To complete experimental tasks to a high quality standard as directed. These tasks will include:

Cell Line Construction

§  Molecular Biology

§  Cell Culture

§  Transfection

§  Automated single cell sorting

§  Automated plate screening

§  Productivity assessments

§  Fed batch assessment (growth, productivity and product quality)

§  Cryopreservation of pre-seed stock

        Bioreactor

§  Preparation of flask inoculum cell cultures

§  Set up and operation of inoculum cell culture bag bioreactors

§  Set-up and operation of miniature (15mL) up to 10L laboratory-scale bioreactors (stirred or air-lift)

§  Daily sampling and nutrient analysis

§  Nutrient feed preparation and additions

§  Harvest and primary recovery


REQUIRED SKILLS:
Candidates will require a background in a biological science. A theoretical knowledge or practical experience in upstream processing (eg. vector construction, transfection, cell line selection, operation of bioreactors, cell culture and aseptic processing, harvesting and primary recovery) would be an advantage but is not essential.

After training successful applicants would be expected to join weekend, bank holiday and on-call rotas.

During busy periods and after appropriate training you may be expected to undertake short term secondments in other departments within Process Development (Purification Development and Process Analytics).

Interested?

Lonza promotes a fast-paced, employee orientated environment and we take pride in both the quality of our products and the success of our employees. We offer a competitive remuneration package and encourage the development of individuals to help them achieve their full potential.

If you are interested in this opportunity please apply online via our careers page. Please ensure that you attach your CV to your profile.

Closing date: 15^th November 2013

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