MedImmune: Scientist I - Extracellular Vesicles/Exosomes - 7849

We are currently recruiting a lab-based Research Scientist to join a new team within the Antibody Discovery and Protein Engineering, based in Cambridge, UK, with responsibility for establishing a platform to generate recombinant extracellular vesicles (exosomes) as targeted delivery vehicles.

Core responsibilities include:

  • Generation of recombinant cell lines to support targeted exosome production
  • Isolation and characterisation of exosomes
  • Identification of methods for incorporating functional content into exosomes
  • Cellular assays and microscopy-based techniques to determine exosome binding and trafficking within target cells
  • Identification of protein-protein interactions involved in the delivery of functional content by exosomes

Your previous experience will provide:

  • Strong expertise and knowledge in the area of extracellular vesicles, including isolation and characterisation of extracellular vesicles/exosomes. Work focused on utilisation as targeted delivery vehicles would be specifically particularly advantageous.
  • Monitoring of intracellular trafficking, with use of confocal microscopy would be desired.
  • You will be expected to have strong bench skills including...
    • Molecular biology (DNA manipulation/cloning)
    • Cell culture and the generation of recombinant cell lines
    • FACS analysis
    • Cell-based assays (binding/potency)
    • Recombinant protein expression (mammalian) and purification
    • Studying of protein-protein interactions.
    • Affinity determination.

Qualifications/Experience: PhD (or equivalent experience) in Cell Biology, Molecular Biology or related discipline.

The successful candidate will display competencies including:

  • Excellent teamwork and communication skills eg. via presentations/reports
  • High degree of scientific and personal integrity
  • Innovative and creative problem solving
  • Strong commitment to quality and best practice

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